Biodegradation characteristics of pharmaceutical substances by whole fungal culture Trametes versicolor and its laccase.

By N. H. Tran, T. Urase, O. Kusakabe. 2010

171 citations recorded by the source corpus.

The degradation of 10 selected pharmaceutically active compounds (PhACs) by whole fungal culture Trametes versicolor, culture filtrates and commercial laccase preparation was conducted. Complete removal of diclofenac (DCF), naproxen (NPX), indomethacin (IDM), ibuprofen (IBP), and fenoprofen (FEP) and partial degradation of other selected PhACs were observed after 48 hours of incubation with the 7-day-old liquid fungal culture both in the presence and absence of ABTS (2,2'-azino-bis(3-ethyl-benzothiazoline-6-sulfonic acid)) as a laccase-mediator. The catalytic activity of laccase in the degradation of selected PhACs was examined for both crude and commercial extracellular laccase preparations. The results showed that laccase preferentially removed DCF, NPX and IDM among the target PhACs removed by the whole fungal culture. Intracellular enzymes may be involved in the degradation of ketoprofen (KEP), clofibric acid (CA), carbamazepine (CBZ), propyphenazone (PPZ), fenoprofen (FEP) and gemfibrozil (GFZ). The removal of most selected PhACs was increased with the increase in laccase activity. The presence of redox mediators such as ABTS and HBT (1-hyroxybenzotriazole) promoted the degradation of selected PhACs, in which complete removal of DCF, NPX and IDM was observed after 3 hours of incubation with laccase activity (2000 U/L) in the presence of ABTS/HBT. The degradation spectrum by laccase for ionic PhACs with nitrogen-containing structure was quite different from that of the activated sludge process.

Subfields: Analytical Chemistry, Plant Science, Pollution

View Paper: https://www.semanticscholar.org/paper/05a6d7a52be74619b3a1f4ef1b0e448f49c19fd4

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In Analytical Chemistry

1. F. Hai
2. L. Nghiem
3. W. Price

In Plant Science

1. F. Hai
2. L. Nghiem
3. W. Price

In Pollution

1. F. Roddick
2. F. Hai
3. L. Nghiem
4. W. Price

Citations in the corpus

• Removal of pharmaceuticals, steroid hormones, phytoestrogens, UV-filters, industrial chemicals and pesticides by Trametes versicolor: Role of biosorption and biodegradation (2014, methodology): “The low removal of the chlorinated TrOC clofibric acid and fenoprop can be explained by the fact that chlorine is a strong EWG. Treatment by laccase from T. versicolor was reported to inefficiently remove clofibric acid (Tran et al., 2010).”
• Degradation of Pharmaceuticals and Personal Care Products by White-Rot Fungi—a Critical Review (2017, methodology): “PPCPs Laccase [80, 81, 89–98] LiP [88, 99, 100] MnP [80, 94, 95, 101]”
• From the conventional biological wastewater treatment to hybrid processes, the evaluation of organic micropollutant removal: A review. (2017, background): “It allowed for high removal rates, especially with some of the most recalcitrant compounds such as CBZ, CFA, DCF, DIU in batch experiments (Bending et al., 2002; Marco-Urrea et al., 2009; Tran et al., 2010; Jeli (cid:1) c et al., 2012a; Margot et al., 2013b).”