Magnetically actuated microrobots as a platform for stem cell transplantation
By Sungwoong Jeon, Sangwon Kim, Shinwon Ha, Seungmin Lee, Eunhee Kim, So Yeun Kim, S. H. Park, Jung Ho Jeon, Sung Won Kim, Cheil Moon and 4 more. Science Robotics, 2019
344 citations recorded by the source corpus.
Magnetic microrobots developed for 3D culture and precise delivery of cells were successfully controlled in various environments. Magnetic microrobots were developed for three-dimensional culture and the precise delivery of stem cells in vitro, ex vivo, and in vivo. Hippocampal neural stem cells attached to the microrobots proliferated and differentiated into astrocytes, oligodendrocytes, and neurons. Moreover, microrobots were used to transport colorectal carcinoma cancer cells to tumor microtissue in a body-on-a-chip, which comprised an in vitro liver-tumor microorgan network. The microrobots were also controlled in a mouse brain slice and rat brain blood vessel. Last, microrobots carrying mesenchymal stem cells derived from human nose were manipulated inside the intraperitoneal cavity of a nude mouse. The results indicate the potential of microrobots for the culture and delivery of stem cells.
Subfields: Biomedical Engineering, Condensed Matter Physics, Physiology
View Paper: https://www.semanticscholar.org/paper/05a60fb1192857f798829614a3ecb11ce10d90e9
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In Biomedical Engineering
Citations in the corpus
- Swarm Robotics: Past, Present, and Future (2021, background): “Finally, swarms of nanobots might, in the future, become a new and powerful tool in precision medicine, making possible targeted interventions within the human body, such as minimally invasive surgery or polytherapy delivery directly to cancerous cells [137], [138].”