The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials

By Weiya Zhang, J. Robertson, A. Jones, Paul A. Dieppe, M. Doherty. Annals of the Rheumatic Diseases, 2008

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Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. (2010, background): “Another possible explanation for the improvement in the placebo group might be that the placebo response is amplified when a treatment is invasive and raises high expectations.(33) This has also been demonstrated previously in a study on the value of injection therapy for the treatment of tendinopat”
Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial (2009, background): “The placebo effect in osteoarthritis treatment has been re-evaluated in a recent meta-analysis showing that it induces significant pain relief, especially in trials involving intra-articular injections.(21) Furthermore, because the actual therapeutic effect of arthrocentesis (with synovial fluid asp”