The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence.

By H. Pohl, H. Welch. Journal of the National Cancer Institute, 2005

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Radiofrequency ablation vs endoscopic surveillance for patients with Barrett esophagus and low-grade dysplasia: a randomized clinical trial. (2014, background): “Of the remaining 17 progressors in the control group, 15 patients (10 high-grade dysplasia, 5 mucosal adenocarcinoma) underwent endoscopic resection plus radiofrequency ablation (n = 9; median [range], 4 resections [1-14]), or radiofrequency ablation (n = 6).”
Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity (2013, background): “In recent decades, the incidence of esophageal adenocarcinoma (EAC) has increased dramatically in the United States and other Western countries 1,2 .”
What are the consequences of the disappearing human microbiota? (2009, background): “The increases that have occurred in recent years in the prevalence of conditions such as obesity and asthma, as well as oesophageal disorders that are a consequence of reflux, have been so rapid that an environmental cause must be presen”
Overdiagnosis in cancer. (2010, background): “This is the pattern that has been reported in esophageal adenocarcinoma (29).”