Deep diversification of an AAV capsid protein by machine learning
By D. Bryant, A. Bashir, Sam Sinai, N. Jain, Pierce J. Ogden, Patrick F. Riley, George M. Church, Lucy J. Colwell, Eric D. Kelsic. 2021
310 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
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Citations in the corpus
- Learning inverse folding from millions of predicted structures (2022, background): “Focusing on mutating a 28-amino acid segment, Bryant et al. (2021) generated more than 200,000 variants of AAV sequences with 12–29 mutations across this region, and measured their ability to package of a DNA payload.”
- Adeno-associated virus as a delivery vector for gene therapy of human diseases (2024, methodology): “A preclinical study was conducted in NHPs using EDIT-103, 231 an investigative gene therapy product containing two rAAV5 vectors to remove endogenous RHO through CRISPR/Cas9 and insert a codon-optimized RHO expression cassette that is resistant to targeted Cas9 cleavage to restore functional RHO…”