MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas
By N. Mäkinen, Miika Mehine, Jaana Tolvanen, Eevi Kaasinen, Yilong Li, Heli J. Lehtonen, M. Gentile, Jian Yan, M. Enge, Minna Taipale and 10 more. Science, 2011
639 citations recorded by the source corpus.
Subfields: Obstetrics and Gynecology, Reproductive Medicine
View Paper: https://www.semanticscholar.org/paper/04db35fca443fcf56c3edd1e24920c5a1ab36693
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In Obstetrics and Gynecology
In Reproductive Medicine
Citations in the corpus
- Evolution and impact of subclonal mutations in chronic lymphocytic leukemia (2013, positive): “Our study thus uncovers patterns of clonal evolution in CLL, providing insights into its stepwise transformation, and links the presence of subclones with adverse clinical outcomes.”
- Uterine fibroid management: from the present to the future (2016, background): “Some specific genetic alterations are linked to fibroid growth (Mäkinen et al., 2011; Eggert et al., 2012; Islam et al., 2013; Mittal et al., 2015; Styer and Rueda, 2015).”
- Transcriptional Addiction in Cancer (2017, positive): “Genetic alterations of Mediator complex-encoding genes are observed frequently in prostate cancer and in many uterine myomas (Allen and Taatjes, 2015; Barbieri et al., 2012; Makinen et al., 2011).”
- Transcriptional Regulation and its Misregulation in Disease (2013, positive): “The MED12 gene is altered in the majority of uterine leiomyomas and its expression is absent in many uterine leiomyosarcomas, the malignant counterparts of leiomyomas (Makinen et al., 2011a; Makinen et al., 2011b).”