The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015
By S. Bhatt, D. Weiss, E. Cameron, D. Bisanzio, B. Mappin, U. Dalrymple, K. Battle, C. Moyes, Andrew J. Henry, P. Eckhoff and 17 more. Nature, 2015
2,784 citations recorded by the source corpus.
Since the year 2000, a concerted campaign against malaria has led to unprecedented levels of intervention coverage across sub-Saharan Africa. Understanding the effect of this control effort is vital to inform future control planning. However, the effect of malaria interventions across the varied epidemiological settings of Africa remains poorly understood owing to the absence of reliable surveillance data and the simplistic approaches underlying current disease estimates. Here we link a large database of malaria field surveys with detailed reconstructions of changing intervention coverage to directly evaluate trends from 2000 to 2015, and quantify the attributable effect of malaria disease control efforts. We found that Plasmodium falciparum infection prevalence in endemic Africa halved and the incidence of clinical disease fell by 40% between 2000 and 2015. We estimate that interventions have averted 663 (542–753 credible interval) million clinical cases since 2000. Insecticide-treated nets, the most widespread intervention, were by far the largest contributor (68% of cases averted). Although still below target levels, current malaria interventions have substantially reduced malaria disease incidence across the continent. Increasing access to these interventions, and maintaining their effectiveness in the face of insecticide and drug resistance, should form a cornerstone of post-2015 control strategies.
Subfields: Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/04ca5f393d81851092fb31f051bf5c320d410b6f
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In Pediatrics, Perinatology and Child Health
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Citations in the corpus
- Bayesian Computing with INLA: A Review (2016, background): “…Africa (Karagiannis-Voules et al., 2015), analysis of the effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015 (Bhatt et al., 2015), adaptive prior weighting in generalized regression (Held and Sauter, 2016), analysis of hand, foot, and mouth disease…”
- Thermal biology of mosquito-borne disease (2019, background): “Already, in the last two decades malaria has declined in Africa (Bhatt et al. 2015) and Latin America (Carter et al. 2015), which may be attributable to interactive effects of climate and malaria control programs (Thomson et al. 2017), while dengue and other viruses transmitted by warm-adapted Ae. a”
- Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 (2024, background): “32 At a time of growing threats to progress against malaria, including emerging parasite and vector resistance and budgetary pressures, but also amid promising new tools such as second vaccine for malaria, it is more important than ever that changing patterns of mortality are quantified and…”
- Spatial modelling with R-INLA: A review (2018, background): “There are several high impact applications using spatial models in R-INLA; in the journal The Lancet Noor et al. (2014) performed a space-time analysis of transmission intensity of malaria and Golding et al. (2017) modeled under-five mortality and neo-natal mortality in multiple countries with separa”