The Contribution of Early Traumatic Events to Schizophrenia in Some Patients: A Traumagenic Neurodevelopmental Model

By John Read, B. Perry, Andre Moskowitz, J. Connolly. Psychiatry, 2001

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Childhood Experience and the Expression of Genetic Potential: What Childhood Neglect Tells Us About Nature and Nurture (2002, background): “…greater risk for meeting diagnostic criterion for autismspectrum disorder, a finding that sheds light on the evolving relationships between early life trauma, neglect and subsequent development of severe neuropsychiatric problems including psychotic disorders and schizophrenia (Read et al., 2001).”
Trauma-Related Intrusions and Psychosis: An Information Processing Account (2004, background): “Others have argued that there is strong evidence suggesting that the effects of trauma exposure on neural networks could provide a potential common diathesis for both PTSD and psychosis ( Read, Perry, Moskowitz and Connolly, 2001; Seedat, Stein, Oosthuizen, Emsley and Stein, 2003).”
The enduring effects of abuse and related adverse experiences in childhood (2006, background): “…cortisol reactivity to stress (Heim 2000,2001). generalized decrease in neurotrophin production, synaptic connectivity,and neuronal survival (Gould and Tanapat 1999; Nibuya 1995; Duman 1997; Gould 1997) resulting in profound abnormalities in brain organization and structure (Perry 2002; Read 2001).”