Molecular mechanisms of antibacterial multidrug resistance.

By M. Alekshun, S. Levy. Cell, 2007

1,613 citations recorded by the source corpus.

Subfields: Ecology

View Paper: https://www.semanticscholar.org/paper/0493d30cf2758f7b41e52d674ca6cba292999bb1

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In Ecology

1. Xian-Zhi Li
2. A. Buschmann
3. H. Nikaido
4. S. Hultgren

Citations in the corpus

• Action and resistance mechanisms of antibiotics: A guide for clinicians (2017, background): “β-lactamases are broadly prevalent enzymes that are classified using two main classification systems: Ambler (structural) and Bush–Jacoby–Medeiros (functional).[15] Ambler classification system is described below: a.”
• Aminoglycoside Modifying Enzymes (2010, background): “Aminoglycoside resistance occurs through several mechanisms that can coexist simultaneously in the same cell (Alekshun and Levy, 2007; Houghton et al., 2010; Magnet and Blanchard, 2005; Taber et al., 1987; Tolmasky, 2007a).”
• Bacterial exposure to ZnO nanoparticles facilitates horizontal transfer of antibiotic resistance genes (2018, background): “Cell membranes are a selective, semi-permeable membrane and constitute an important barrier for the horizontal transfer of genetic information between aquatic microbiota of different species or genera (Alekshun and Levy, 2007; Thomas and Nielsen, 2005).”
• ARDB—Antibiotic Resistance Genes Database (2008, neutral): “Several mechanisms have been characterized through which bacteria become resistant to antibiotics (8): (i) the production of enzymes that digest/metabolize the antibiotic; (ii) efflux pumps that eliminate the drug from the cell; (iii) modifications to the cellular target of the antibiotic that preve”
• Efflux-Mediated Drug Resistance in Bacteria: an Update (2009, background): “Although antibacterial resistance occurs by numerous mechanisms, including enzymatic inactivation or modification of drugs, drug target alteration or protection, and lack of pro-drug activation, that due to the increased active efflux of the drugs is a major concern especially because a single speci”
• Antimicrobial resistance in aquaculture: a crisis for concern (2020, background): “Most of the antibiotic resistance genes on R plasmids reside on transposons, help in the rapid spread of genetic determinants (Alekshun and Levy 2007).”
• Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems (2008, background): “Since the discovery of antibiotics in the early 20th century, many pathogenic bacteria have developed resistance mechanisms that abolish the efficiency of therapies, and other species are intrinsically resistant to some antibiotics (5).”
• Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health. (2013, background): “The modular nature of the MGE involved in antimicrobial resistance in aquatic bacteria also facilitates selection of multiple antimicrobial resistances by a single antimicrobial compound and by other antimicrobial compounds used in aquaculture such as heavy metals and disinfectants (Herwig and Gray,”
• Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment. (2015, background): “…pathogens, e.g. Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, vancomycin-resistant Enterococcus, and extensively drug-resistant Mycobacterium tuberculosis (Alekshun and Levy, 2007).”