Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.

By Alan S. Go, Glenn M. Chertow, Dongjie Fan, Charles E. McCulloch, Chi-yuan Hsu. New England Journal of Medicine, 2004

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Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. (2007, background): “In particular, cardiovascular events and mortality increase as the estimated glomerular filtration rate (eGFR) declines below 60 ml/min.(4) In dialysis patients, cardiovascular disease is 10- to 20-fold higher than the general population, representing at least half of the 15–25% per year mortality r”
The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. (2011, methodology): “9,10 The role of proteinuria as well as GFR measurements in assessing risk of CKD is particularly important since people with stage 1–2 CKD and proteinuria have worse outcomes than people with stage 3 and no proteinuria, and development of both ESRD and cardiovascular disease is predicted much more ”
A systematic analysis of world-wide population-based data on the global burden of chronic kidney disease in 2010 (2015, methodology): “It is well documented that CVD causes most of the deaths in patients with CKD (2,3).”