Shaping humoral immunity to vaccines through antigen-displaying nanoparticles

By D. Irvine, Benjamin J. Read. 2020

115 citations recorded by the source corpus.

Strategies to qualitatively and quantitatively enhance the humoral response to immunizations with protein and polysaccharide antigens are of broad interest for development of new and more effective vaccines. A strategy of increasing importance is the formulation of antigens into a particulate format, mimicking the physical form of viruses. The potential benefits of enhanced B cell receptor engagement by nanoparticles have been long been appreciated, but recent studies are defining additional important factors governing how nanoparticle immunogens interact with the immune system in the context of lymphoid organs. This review will discuss findings about how nanoparticles enhance humoral immunity in vivo and factors governing the fate of nanoparticle immunogens in lymph nodes.

Subfields: Immunology

Citations in the corpus

• Vaccine adjuvants: mechanisms and platforms (2023, unknown): “Moreover, considering that the combination of immunostimulants (mainly PRRs agonists) and delivery systems (especially nanoparticle delivery systems) are currently used for adjuvants development to achieve higher immune activation.(84,333) Here, some issues need to be carefully considered.”