Mouse Genome Database (MGD) 2019

By Carol J. Bult, Judith A. Blake, Cynthia L. Smith, J. Kadin, J. Richardson, The Mouse Genome Database Group. Nucleic Acids Res., 2018

601 citations recorded by the source corpus.

Abstract The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism genetic and genome resource for the laboratory mouse. MGD is the authoritative source for biological reference data sets related to mouse genes, gene functions, phenotypes, and mouse models of human disease. MGD is the primary outlet for official gene, allele and mouse strain nomenclature based on the guidelines set by the International Committee on Standardized Nomenclature for Mice. In this report we describe significant enhancements to MGD, including two new graphical user interfaces: (i) the Multi Genome Viewer for exploring the genomes of multiple mouse strains and (ii) the Phenotype-Gene Expression matrix which was developed in collaboration with the Gene Expression Database (GXD) and allows researchers to compare gene expression and phenotype annotations for mouse genes. Other recent improvements include enhanced efficiency of our literature curation processes and the incorporation of Transcriptional Start Site (TSS) annotations from RIKEN’s FANTOM 5 initiative.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0414f6ffc086bf6c2015176d4b46a051d436cd2b

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In Molecular Biology

Citations in the corpus

Mendelian Gene Discovery: Fast and Furious with No End in Sight. (2019, background): “Use of transcriptome sequencing (RNA-seq) to identify abnormally spliced transcripts and/or assess transcript abundance facilitates identiﬁcation of non-coding variants, deep intronic splice variants, 16–18 and to a lesser extent, synonymous variants with unexpected effects on splicing.”
The Gene Ontology knowledgebase in 2023 (2023, unknown): “MGI* (Bult et al. 2019) Mouse 106,435 8,051 Reactome* (Fabregat et al.”
Structural Predictions of the SNX-RGS Proteins Suggest They Belong to a New Class of Lipid Transfer Proteins (2021, unknown): “In mice SNX13, SNX14 and SNX25 are all essential for normal development (Bryant et al., 2020; Bult et al., 2019; Zheng et al., 2006), while altering the expression of Snz significantly extends the lifespan of flies (Ugrankar et al.”