Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer's disease

By Kassandra Kisler, Amy R. Nelson, Axel Montagne, Berislav Zlokovic. Nature Reviews Neuroscience, 2017

1,068 citations recorded by the source corpus.

Cerebral blood flow (CBF) regulation is essential for normal brain function. The mammalian brain has evolved a unique mechanism for CBF control known as neurovascular coupling. This mechanism ensures a rapid increase in the rate of CBF and oxygen delivery to activated brain structures. The neurovascular unit is composed of astrocytes, mural vascular smooth muscle cells and pericytes, and endothelia, and regulates neurovascular coupling. This Review article examines the cellular and molecular mechanisms within the neurovascular unit that contribute to CBF control, and neurovascular dysfunction in neurodegenerative disorders such as Alzheimer disease.

Subfields: Neurology

View Paper: https://www.semanticscholar.org/paper/04102fb60ae2f42f8899d92d1642adec855af4d2

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Citations in the corpus

3D Self-Organized Microvascular Model of the Human Blood-Brain Barrier with Endothelial Cells, Pericytes and Astrocytes (2018, background): “However, systems to date have relatively large diameters (~600e800 mm) [27] compared to the dimension of human BBB vasculature in vivo (arterioles and venules 10e90 mm; capillaries 7e10 mm) [4,28,29], and fail to recapitulate BBB microvasculature morphology and development in terms of mature cell-ce”
Multi-sensory gamma stimulation ameliorates Alzheimer’s-associated pathology and improves cognition. (2019, background): “Astrocytes are another primary glial cell in the CNS and are critical for many important biological processes including waste clearance (Chung et al., 2015; Kisler et al., 2017).”