Faculty Opinions recommendation of Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA.

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Phototropin blue-light receptors. (2007, background): “An important question to address now is whether LOV2 acts as a dark-state repressor of phototropin kinase activity or a light- NMR: nuclear magnetic resonance PKA: protein kinase A state activator.”
Structural basis for cAMP-mediated allosteric control of the catabolite activator protein (2009, background): “This group includes, among many others, protein kinase A (29), guanine nucleotide exchange factors (30), and ion channels that regulate metal ion gating (31).”
A glimpse of structural biology through X-ray crystallography. (2014, background): “Subsequent structural analysis of PKA with both catalytic and regulatory subunits provides a molecular explanation for the inhibition of PKA and identifies amodel for cAMP-mediated activation through binding to the regulatory subunit (Figure 3B) (Kim et al., 2005; Wu et al., 2007).”
Regulation of lipolysis in adipocytes. (2007, unknown): “cAMP binds PKA, causing the regulatory subunits to dissociate from the catalytically active subunits, resulting in increased activity of the enzyme (60).”