Endogenous DNA Damage as a Source of Genomic Instability in Cancer
By Anthony Tubbs, A. Nussenzweig. Cell, 2017
1,262 citations recorded by the source corpus.
Genome instability, defined as higher than normal rates of mutation, is a double-edged sword. As a source of genetic diversity and natural selection, mutations are beneficial for evolution. On the other hand, genomic instability can have catastrophic consequences for age-related diseases such as cancer. Mutations arise either from inactivation of DNA repair pathways or in a repair-competent background due to genotoxic stress from celluar processes such as transcription and replication that overwhelm high-fidelity DNA repair. Here, we review recent studies that shed light on endogenous sources of mutation and epigenomic features that promote genomic instability during cancer evolution.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/03b41a4e5fb61e32e8b4243feb71cf878482a476
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In Cancer Research
In Molecular Biology
Citations in the corpus
- DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy (2021, background): “It is critical for maintaining genomic DNA stability due to its role as the template for replication and transcription.(79) As described above, damage to DNA from environmental hazards insult as well as endogenous toxic agents such as free radicals can compromise genome stability and cause or promot”