Advances in single-molecule fluorescence methods for molecular biology.

By Chirlmin Joo, H. Balci, Y. Ishitsuka, C. Buranachai, T. Ha. Annual Review of Biochemistry, 2008

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Video imaging of walking myosin V by high-speed atomic force microscopy (2010, background): “as a foot stomp: (1) an entire head disappears and then reappears at approximately the same position; (2) either motor domain of a two-headed bound M5-”
Learning rates and states from biophysical time series: a Bayesian approach to model selection and single-molecule FRET data. (2009, background): “L = p(y|θ) = Π i=1 N (yi − fθ(xi)|0, σ) = e−χ 2 ( √ 2πσ)N (11) with the usual χ(2) = ∑i=N i=1 (yi − fθ(xi))(2)/σ(2) arising as a linear term in the logarithm of the likelihood `:”
Photophysics of Fluorescence Probes for Single Molecule Biophysics and Super-Resolution Imaging (2012, positive): “Started as a novel pursuit of physical scientists, detection of single fluorophores rapidly moved into the main stream applications in biological sciences(2), ranging from studies of central dogma enzymes(3–5) and membrane processes (6) and to the various processes involved in infectious diseases an”
A BIRD’S EYE VIEW: TRACKING SLOW NANOMETER-SCALE MOVEMENTS OF SINGLE MOLECULAR NANO-ASSEMBLIES (2010, positive): “Fluorescence-based tools are now being employed to understand the properties and dynamics of proteins (Giepmans et al., 2006; Min et al., 2005; Schuler and Eaton, 2008; Shi et al., 2008) and nucleic acids (Ditzler et al., 2007; Joo et al., 2008; Pljevaljcic and Millar, 2008; Zhao and Rueda, 2009).”