Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe.

By Teresa M. Coque, F. Baquero, R. Cantón. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2008

834 citations recorded by the source corpus.

Extended-spectrum beta-lactamases (ESBLs) have been increasingly reported in Europe since their first description in 1983. During the 1990s, they were described mainly as members of the TEM- and SHV-beta-lactamase families in Klebsiella pneumoniae causing nosocomial outbreaks. Nowadays, they are mostly found in Escherichia coli that cause community-acquired infections and with increasing frequency contain CTX-M enzymes. Dissemination of specific clones or clonal groups and epidemic plasmids in community and nosocomial settings has been the main reason for the increase in most of the widespread ESBLs belonging to the TEM (TEM-24, TEM-4, TEM-52), SHV (SHV-5, SHV-12) and CTX-M (CTX-M-9, CTX-M-3, CTX-M-14 or CTX-M-15) families in Europe. Co-selection with other resistances, especially to fluoroquinolones, aminoglycosides and sulfonamides, seems to have contributed to the problem. The emergence of epidemic clones harbouring several beta-lactamases simultaneously (ESBLs, metallo-beta-lactamases or cephamycinases) and of new mechanisms of resistance to fluoroquinolones and aminoglycosides warrants future surveillance studies.

Subfields: Epidemiology, Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/02d074ed6471def2ffba3cb0dd83c2a1ac283751

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

A. Carattoli

In Molecular Medicine

Citations in the corpus

Resistance Plasmid Families in Enterobacteriaceae (2009, background): “Other CTX-M variants are amplified locally, such as CTXM-9 and CTX-M-14 in both Portugal and Spain and CTX-M-3 in Eastern European countries (24, 74, 77).”
Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment. (2015, background): “Isolates with the CTX-M-9 group are common in Spain and strains with the CTX-M-3 enzymes have been described chiefly in Eastern Europe, although clones producing the CTX-M group 1 (including the CTX-M-15 type) are the most widespread throughout Europe (Coque et al., 2008a,b; Canton et al., 2008).”
CTX-M Enzymes: Origin and Diffusion (2012, background): “…class A β-lactamases, the extended-spectrum β-lactamases (ESBLs) which are able to hydrolyze expandedspectrum cephalosporins (such as cefotaxime, ceftriaxone, ceftazidime, or cefepime) and monobactams (aztreonam) represent a public health concern (Coque et al., 2008a; Pitout and Laupland, 2008).”