Cellular and molecular mechanisms of repair in acute and chronic wound healing

By Paul Martin, Paul Martin, R. Nunan. British Journal of Dermatology, 2015

970 citations recorded by the source corpus.

A considerable understanding of the fundamental cellular and molecular mechanisms underpinning healthy acute wound healing has been gleaned from studying various animal models, and we are now unravelling the mechanisms that lead to chronic wounds and pathological healing including fibrosis. A small cut will normally heal in days through tight orchestration of cell migration and appropriate levels of inflammation, innervation and angiogenesis. Major surgeries may take several weeks to heal and leave behind a noticeable scar. At the extreme end, chronic wounds – defined as a barrier defect that has not healed in 3 months – have become a major therapeutic challenge throughout the Western world and will only increase as our populations advance in age, and with the increasing incidence of diabetes, obesity and vascular disorders. Here we describe the clinical problems and how, through better dialogue between basic researchers and clinicians, we may extend our current knowledge to enable the development of novel potential therapeutic treatments.

Subfields: Dermatology, Rehabilitation, Urology

View Paper: https://www.semanticscholar.org/paper/02bb7bf13e33a8c9625e3a4ba712c7ab7366bbb2

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Citations in the corpus

Treatment Strategies for Infected Wounds (2018, neutral): “Many details of the complex process of wound healing can be found in a recent report by Martin and Nunan [35].”
Skin Acute Wound Healing: A Comprehensive Review (2019, background): “Macrophages increase their numbers during the inflammation phase, reach maximum concentration during the proliferation phase, and decline progressively during the remodeling phase, being the most abundant cell in all phases of wound repair [63, 115].”