Peroxiredoxins are conserved markers of circadian rhythms
By Rachel S. Edgar, E. W. Green, Yuwei Zhao, Gerben van Ooijen, María Olmedo, Ximing Qin, Yao Xu, Min Pan, U. Valekunja, K. Feeney and 9 more. Nature, 2012
874 citations recorded by the source corpus.
Cellular life emerged ∼3.7 billion years ago. With scant exception, terrestrial organisms have evolved under predictable daily cycles owing to the Earth’s rotation. The advantage conferred on organisms that anticipate such environmental cycles has driven the evolution of endogenous circadian rhythms that tune internal physiology to external conditions. The molecular phylogeny of mechanisms driving these rhythms has been difficult to dissect because identified clock genes and proteins are not conserved across the domains of life: Bacteria, Archaea and Eukaryota. Here we show that oxidation–reduction cycles of peroxiredoxin proteins constitute a universal marker for circadian rhythms in all domains of life, by characterizing their oscillations in a variety of model organisms. Furthermore, we explore the interconnectivity between these metabolic cycles and transcription–translation feedback loops of the clockwork in each system. Our results suggest an intimate co-evolution of cellular timekeeping with redox homeostatic mechanisms after the Great Oxidation Event ∼2.5 billion years ago.
Subfields: Aging, Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems
View Paper: https://www.semanticscholar.org/paper/028e7fca1233125c3d3f0d86f0a781a7d4c2c2bc
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Citations in the corpus
- The two‐process model of sleep regulation: a reappraisal (2016, background): “The oxidation–reduction cycles of peroxiredoxin proteins has been proposed to constitute a universal marker for circadian rhythms in all domains of life (Edgar et al., 2012).”
- Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease (2017, background): “On the other, oxidant species, such as superoxide and hydrogen peroxide, can function as signaling molecules in a broad array of essential redox-dependent signaling pathways that are critical for the organismal survival including epidermal growth factor receptor signaling [202], inactivation of the ”
- Molecular components of the Mammalian circadian clock. (2013, background): “The peroxiredoxin oscillators are remarkably conserved among all phyla that have been examined (Edgar et al. 2012).”
- Emerging methods in protein co-evolution (2013, methodology): “The functional interconnectivity of these seemingly disparate processes was shown by the oxidation–reduction cycles of peroxiredoxin proteins being universal markers for circadian rhythms across bacteria, archaea and eukaryotes, despite the large mechanistic differences 109 .”
- Minimal tool set for a prokaryotic circadian clock (2016, background): “However, findings on post-translational systems are accumulating [16–18] and might exist also in Archaea [16].”
- Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. (2014, methodology): “All three domains of life —archaea, bacteria, and eukarya—have evolved different methods of developing molecular machineries to coordinate this task (Edgar et al., 2012).”