Intraretinal Layer Segmentation of Macular Optical Coherence Tomography Images Using Optimal 3-D Graph Search
By Mona Kathryn Garvin, Michael David Abràmoff, R. Kardon, S. Russell, Xiaodong Wu, Milan Sonka. IEEE Transactions on Medical Imaging, 2008
362 citations recorded by the source corpus.
Current techniques for segmenting macular optical coherence tomography (OCT) images have been 2-D in nature. Furthermore, commercially available OCT systems have only focused on segmenting a single layer of the retina, even though each intraretinal layer may be affected differently by disease. We report an automated approach for segmenting (anisotropic) 3-D macular OCT scans into five layers. Each macular OCT dataset consisted of six linear radial scans centered at the fovea. The six surfaces defining the five layers were identified on each 3-D composite image by transforming the segmentation task into that of finding a minimum-cost closed set in a geometric graph constructed from edge/regional information and a priori determined surface smoothness and interaction constraints. The method was applied to the macular OCT scans of 12 patients (24 3-D composite image datasets) with unilateral anterior ischemic optic neuropathy (AION). Using the average of three experts' tracings as a reference standard resulted in an overall mean unsigned border positioning error of 6.1 plusmn 2.9 mum, a result comparable to the interobserver variability (6.9 plusmn 3.3 mum).Our quantitative analysis of the automated segmentation results from AION subject data revealed that the inner retinal layer thickness for the affected eye was 24.1 mum (21%) smaller on average than for the unaffected eye (p < 0.001), supporting the need for segmenting the layers separately.
Subfields: Biomedical Engineering, Ophthalmology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/023fdecc9660f78a88619b0b82cbe9863b526876
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Citations in the corpus
- Retinal Imaging and Image Analysis (2010, positive): “[123]–[126] reported the first true 3-D segmentation approach for the segmentation of retinal layers on OCT scans, thus taking advantage of 3-D contextual information.”
- Automated 3-D Intraretinal Layer Segmentation of Macular Spectral-Domain Optical Coherence Tomography Images (2009, methodology): “, see [14], [15]), the incorporation of regional information is often limited to a region immediately surrounding the voxel for which the cost is defined (especially in cases of multiple surface detection).”