A Red Carpet for Iron Metabolism
By M. Muckenthaler, S. Rivella, Matthias W. Hentze, B. Galy. Cell, 2017
1,141 citations recorded by the source corpus.
200 billion red blood cells (RBCs) are produced every day, requiring more than 2 × 3 1015 iron atoms every second to maintain adequate erythropoiesis. These numbers translate into 20 mL of blood being produced each day, containing 6 g of hemoglobin and 20 mg of iron. These impressive numbers illustrate why the making and breaking of RBCs is at the heart of iron physiology, providing an ideal context to discuss recent progress in understanding the systemic and cellular mechanisms that underlie the regulation of iron homeostasis and its disorders.
Subfields: Genetics, Hematology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/021fd01e7e7af1ce733c059ec75fbd3eda106afe
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Citations in the corpus
- The Roles of NRF2 in Modulating Cellular Iron Homeostasis (2017, background): “High labile iron pool levels lead to destruction of IRPs through proteasomal degradation, while low labile iron stabilizes them (103, 104, 132, 158, 163).”
- Iron metabolism and iron disorders revisited in the hepcidin era (2020, neutral): “They also recover heme from hemoglobin (Hb)-haptoglobin (HP) or heme-hemopexin (HPX) complexes.(2) Iron not used inside the cells is either stored in FT or exported to the circulation by FPN with the cooperation of ceruloplasmin (CP).”