Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial

By M. Bolland, P. Barber, R. Doughty, B. Mason, A. Horne, R. Ames, G. Gamble, A. Grey, I. Reid. British medical journal, 2008

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Calcium metabolism in health and disease. (2010, background): “A large clinical trial in healthy postmenopausal women recently reported an association between calcium supplementation and increased rates of cardiovascular events (45).”
Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis (2011, background): “Calcium supplements, with or without vitamin D, are widely used for the prevention and treatment of osteoporosis. Recently, we reported increases in rates of cardiovascular events in women allocated to calcium supplements in the Auckland Calcium Study, a five year randomised, placebo controlled tria”
Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis (2010, background): “Furthermore, a five year randomised controlled trial of calcium supplements in healthy older women, in which cardiovascular events were prespecified as secondary end points, recently reported possible increases in rates of myocardial infarction and cardiovascular events in women allocated to calcium”