Congenital Zika Syndrome: Characterizing the Pattern of Anomalies for Pediatric Healthcare Providers
By C. Moore, J. E. Staples, W. Dobyns, A. Pessoa, C. Ventura, E. Fonseca, E. Ribeiro, Liana O Ventura, Norberto Nogueira Neto, J. Arena and 1 more. JAMA pediatrics, 2017
827 citations recorded by the source corpus.
Importance Zika virus infection can be prenatally passed from a pregnant woman to her fetus. There is sufficient evidence to conclude that intrauterine Zika virus infection is a cause of microcephaly and serious brain anomalies, but the full spectrum of anomalies has not been delineated. To inform pediatric clinicians who may be called on to evaluate and treat affected infants and children, we review the most recent evidence to better characterize congenital Zika syndrome. Observations We reviewed published reports of congenital anomalies occurring in fetuses or infants with presumed or laboratory-confirmed intrauterine Zika virus infection. We conducted a comprehensive search of the English literature using Medline and EMBASE for Zika from inception through September 30, 2016. Congenital anomalies were considered in the context of the presumed pathogenetic mechanism related to the neurotropic properties of the virus. We conclude that congenital Zika syndrome is a recognizable pattern of structural anomalies and functional disabilities secondary to central and, perhaps, peripheral nervous system damage. Although many of the components of this syndrome, such as cognitive, sensory, and motor disabilities, are shared by other congenital infections, there are 5 features that are rarely seen with other congenital infections or are unique to congenital Zika virus infection: (1) severe microcephaly with partially collapsed skull; (2) thin cerebral cortices with subcortical calcifications; (3) macular scarring and focal pigmentary retinal mottling; (4) congenital contractures; and (5) marked early hypertonia and symptoms of extrapyramidal involvement. Conclusions and Relevance Although the full spectrum of adverse reproductive outcomes caused by Zika virus infection is not yet determined, a distinctive phenotype—the congenital Zika syndrome—has emerged. Recognition of this phenotype by clinicians for infants and children can help ensure appropriate etiologic evaluation and comprehensive clinical investigation to define the range of anomalies in an affected infant as well as determine essential follow-up and ongoing care.
Subfields: Infectious Diseases, Public Health, Environmental and Occupational Health, Rheumatology
View Paper: https://www.semanticscholar.org/paper/01df30f7a9451fc4cf1b039ccb76b1c73fb9fe99
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Public Health, Environmental and Occupational Health
Citations in the corpus
- Brain organoids: advances, applications and challenges (2019, background): “Despite the difficulty in collecting human brain samples with consistent quality, analyses of these samples have continued to expand our knowledge of normal and diseased human brains (Calvet et al., 2016; Hansen et al., 2010; Moore et al., 2017; Nowakowski et al., 2016; Ozair et al., 2018; Pollen et”
- Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know (2020, background): “merging infections have been E shown to have an important impact on pregnant women and their fetuses,(1) with the increased risk of complications in pregnant women with the 2009 pandemicH1N1 influenza virus(2) and the severe fetal effects of Zika virus as recent examples.(3,4) The emergence of a cor”