PEGylated Nano-Graphene Oxide for Delivery of Water Insoluble Cancer Drugs

By Zhuang Liu, J. Robinson, Xiaoming Sun, Hongjie Dai. Journal of the American Chemical Society, 2008

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It is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment. In this work, we functionalized nano-graphene oxide (NGO), a novel graphitic material, with branched polyethylene glycol (PEG) to obtain a biocompatible NGO-PEG conjugate stable in various biological solutions, and used them for attaching hydrophobic aromatic molecules including a camptothecin (CPT) analog, SN38 non-covalently via π-π stacking. The resulting NGO-PEG-SN38 complex exhibited excellent water solubility while maintaining its high cancer cell killing potency similar to that of the free SN38 molecules in organic solvents. The efficacy of NGO-PEG-SN38 was far higher than that of irinotecan (CPT-11), a FDA approved water soluble SN38 prodrug used for the treatment of colon cancer. Our results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs.

Subfields: Biomaterials, Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/01c69b292ecd056c6b53c2a8fb939e4556ddc308

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Graphene-based antibacterial paper. (2010, background): “Very recently, graphene paper has been found to be a biocompatible substrate for adhesion and proliferation of L-929 cells,(20) neuroendocrine PC12 cells, oligodendroglia cells, and osteoblasts,(34) and graphene oxide has been employed as an effective nanocargo to deliver water-insoluble drugs into ”