RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

By A. Pichlmair, O. Schulz, C. Tan, T. Näslund, P. Liljeström, F. Weber, C. Reis e Sousa. Science, 2006

2,339 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0185dd2a4f52d2bb434c3a005ace819bc725bbd9

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In Immunology

1. Shizuo Akira
2. Taro Kawai
3. O. Takeuchi
4. Zhijian J. Chen
5. T. Mogensen
6. R. Medzhitov
7. R. Randall
8. M. Gale

In Molecular Biology

1. Shizuo Akira
2. Taro Kawai
3. Zhijian J. Chen
4. O. Takeuchi
5. D. Tang
6. R. Kang
7. M. Gale
8. T. Mogensen

Citations in the corpus

• Viral evasion and subversion of pattern-recognition receptor signalling (2008, background): “This led the authors to conclude that RIG-I actually recognized influenza A virus genomic single-stranded RNA containing a 5′ triphosphate 51 .”
• Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. (2019, neutral): “14 Cell 177, 1–16, May 2, 2019 (Figures 2A and 2B), probably due to the fact that MDA5 binds to long dsRNAs (Kato et al., 2008), and RIG-I binds to intracellular 50-triphosphate single-stranded RNA and panhandle-like blunt-end 50-triphosphate dsRNA (Kowalinski et al., 2011; Pichlmair et al., 2006).”
• ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA (2015, background): “…double-stranded RNA (dsRNA) ends containing either 50 triphosphate (ppp) or 50 diphosphate (pp) moieties (Goubau et al., 2014; Hornung et al., 2006; Pichlmair et al., 2006; Schlee et al., 2009; Schmidt et al., 2009) and not 2’ OH methylated at the first 5’ terminal nucleotide (Schuberth-Wagner et…”
• The multifunctional NS1 protein of influenza A viruses. (2008, background): “As such, recent work now indicates that PR8/NS1 may mediate its pre-transcriptional block on IFN-b induction by forming a complex with RIG-I (Guo et al., 2007; Mibayashi et al., 2007; Opitz et al., 2007; Pichlmair et al., 2006).”
• Structural and functional insights into pattern recognition by the innate immune receptor RIG-I (2010, background): “Two initial studies independently established that RIG-I specifically targets 5′-triphosphate–containing viral RNA”
• Structural insights into RNA recognition by RIG-I (2011, neutral): “It is generally accepted that RIG-I can be activated by 5’triphosphate (5’ppp) ssRNA or dsRNA (Hornung et al., 2006; Kato et al., 2006; Lu et al., 2010; Pichlmair et al., 2006; Wang et al., 2010b).”
• Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I (2009, background): “In addition, it has recently been shown that NS1 interacts with RIG-I and efficiently suppresses its signal transducing activity (Guo et al., 2007; Mibayashi et al., 2007; Opitz et al., 2006; Pichlmair et al., 2006).”