Nutritional immunity: transition metals at the pathogen-host interface

By M. Hood, Eric P. Skaar. Nature Reviews Microbiology, 2012

1,472 citations recorded by the source corpus.

Transition metals occupy an essential niche in biological systems. Their electrostatic properties stabilize substrates or reaction intermediates in the active sites of enzymes, and their heightened reactivity is harnessed for catalysis. However, this heightened activity also renders transition metals toxic at high concentrations. Bacteria, like all living organisms, must regulate their intracellular levels of these elements to satisfy their physiological needs while avoiding harm. It is therefore not surprising that the host capitalizes on both the essentiality and toxicity of transition metals to defend against bacterial invaders. This Review discusses established and emerging paradigms in nutrient metal homeostasis at the pathogen–host interface.

Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/0112232947bfa4eb112be4e9ed4a59a2764fc5d6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. Taiho Kambe
2. C. Rensing
3. Ayako Hashimoto
4. Tokuji Tsuji
5. Naoya Itsumura

In Nutrition and Dietetics

1. F. Powrie
2. G. Weiss
3. Taiho Kambe
4. C. Rensing
5. Ayako Hashimoto
6. U. Schaible
7. Tokuji Tsuji
8. Naoya Itsumura

Citations in the corpus

• Macrophage defense mechanisms against intracellular bacteria (2015, background): “In addition, S100 proteins can be induced by IL-17 and IL22, and S100 proteins exert pro-inflammatory activity and may promote chemotaxis of PMN (233, 244).”
• The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages (2019, background): “Calprotectin is a well-studied antimicrobial protein that is capable of enhancing bacterial killing via different mechanisms such as sequestration of metal ions such as zinc (Zn) andmanganese (Mn) (Hood and Skaar, 2012; Kehl-Fie et al., 2011).”
• The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism. (2015, background): “Here, the microbial pathogen is starved of micronutrients through spatial isolation (164).”
• Identification of a domain critical for Staphylococcus aureus LukED receptor targeting and lysis of erythrocytes (2020, background): “Host organisms employ nutritional immunity to prevent the acquisition of iron and other metals by pathogens, and thus successful pathogens must devise strategies to acquire these essential nutrients (17, 18).”
• Engineering plants for heavy metal stress tolerance (2018, positive): “It also orchestrate the generation of many reactive oxygen species (ROS), including hydrogen peroxide, superoxides, which are strong oxidants, causing oxidation to bilayered lipid membranes and biopolymers (Hood and Skaar, 2012).”
• Metal Homeostasis and Resistance in Bacteria (2017, background): “A novel sensor of NADH/ NAD+ redox poise in Streptomyces coelicolor A3(2).”