Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

By Alberto Elosegui-Artola, R. Oria, Yunfeng Chen, A. Kosmalska, Carlos Pérez-González, N. Castro, Cheng-Long Zhu, X. Trepat, Pere Roca-Cusachs. Nature Cell Biology, 2016

738 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/00fa1f7a6cbdbea542f604b82c78b30be9324cb7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. X. Trepat
2. R. Fässler
3. Thomas Andrew Waigh

In Immunology and Allergy

1. R. Fässler

Citations in the corpus

• Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores. (2017, positive): “To verify the respective roles of thesemolecular players versus direct nuclear force, we seeded cells on stiff substrates and abrogated YAP nuclear localization, focal adhesions, and cytoskeletal force transmission by either depolymerizing actin with 2 mM cytochalasin D (Figures S2A–S2F) or depletin”
• Integrin-mediated mechanotransduction (2016, background): “Interestingly, under cyclic stretch, MRTF–SRF activation precedes and facilitates YAP/ JCB • Volume 215 • NumBer 4 • 2016452 TAZ activation, suggesting that MRTF–SRF activation is responsible for immediate transcriptional response to mechanical stimulus (Cui et al., 2015).”