Brassinosteroid, gibberellin, and phytochrome impinge on a common transcription module in Arabidopsis

By Ming-Yi Bai, Jianxiu Shang, Eunkyoo Oh, Min Fan, Yang Bai, Rodolfo Zentella, Tai-ping Sun, Zhi-Yong Wang. Nature Cell Biology, 2012

612 citations recorded by the source corpus.

Brassinosteroid and gibberellin promote many similar developmental responses in plants; however, their relationship remains unclear. Here we show that BR and GA act interdependently through a direct interaction between the BR-activated BZR1 and GA-inactivated DELLA transcription regulators. GA promotion of cell elongation required BR signalling, whereas BR or active BZR1 suppressed the GA-deficient dwarf phenotype. DELLAs directly interacted with BZR1 and inhibited BZR1–DNA binding both in vitro and in vivo. Genome-wide analysis defined a BZR1-dependent GA-regulated transcriptome, which is enriched with light-regulated genes and genes involved in cell wall synthesis and photosynthesis/chloroplast function. GA promotion of hypocotyl elongation requires both BZR1 and the phytochrome-interacting factors (PIFs), as well as their common downstream targets encoding the PRE-family helix–loop–helix factors. The results demonstrate that GA releases DELLA-mediated inhibition of BZR1, and that the DELLA–BZR1–PIF4 interaction defines a core transcription module that mediates coordinated growth regulation by GA, BR and light signals.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/00b16b7111a54573b39b245e185399a34c4ab7c9

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In Molecular Biology

1. P. Achard
2. J. Davière
3. Stephen G Thomas
4. Sunghwa Choe
5. M. Gururani
6. P. Hedden
7. J. Venkatesh
8. Yuhee Chung

In Plant Science

1. P. Achard
2. J. Davière
3. Stephen G Thomas
4. Sunghwa Choe
5. M. Gururani
6. P. Hedden
7. J. Venkatesh
8. Yuhee Chung

Citations in the corpus

• Gibberellin signaling in plants (2013, background): “For example, DELLAs regulate hypocotyl elongation by interacting with PHYTOCHROME INTERACTING FACTORS (PIFs) (de Lucas et al., 2008; Feng et al., 2008; Gallego-Bartolomé et al., 2010) and BRASSINAZOLE RESISTANT1 (BZR1) (Bai et al., 2012; Gallego-Bartolomé et al., 2012), they control floral transitio”
• Brassinosteroids: Multidimensional Regulators of Plant Growth, Development, and Stress Responses[OPEN] (2019, background): “RGA1 At2g01570 Together with other DELLA proteins, inhibits BES1, BZR1, PIF4, and ARF6 under low GA conditions (Bai et al., 2012b; Gallego-Bartolomé et al., 2012)”
• Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “Hence, it is possible that AhNRAMP1 also transports other”
• The Regulation of Brassinosteroid Biosynthesis in Arabidopsis (2013, background): “DELLA proteins, which are degraded in response to GA, were shown to bind BZR1 and thereby prevent BZR1 from binding to its target DNA, thus forming a critical link between BZR1 and the photomorphogenic regulatory system (Bai et al., 2012).”
• The role of gibberellin signalling in plant responses to abiotic stress (2014, background): “Several DELLA-interacting proteins have been shown to be components of other hormone signalling pathways, providing a mechanism for GA signalling to interact with these pathways (Bai et al., 2012; Gallego-Bartolomé et al., 2012; Hou et al., 2010).”
• Regulation of Photosynthesis during Abiotic Stress-Induced Photoinhibition. (2015, background): “…1351 activation factor) and CUC (cup-shaped cotyledon)] 2 TF (Ha et al., 2014); BR, brassinosteroid; 1352 BZR1, brassinazole resistant 1 TF (Bai et al., 2012); CRF6, cytokinin response factor 6 (Zwack 1353 et al., 2013); CK, cytokinin; Cytb6f, cytochrome b6f complex; ERF6, ethylene…”