Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression.

By Andres M. Lozano, Helen S. Mayberg, P. Giacobbe, Clement Hamani, R. Craddock, Sidney H. Kennedy. Biological Psychiatry, 2008

983 citations recorded by the source corpus.

Subfields: Neurology

View Paper: https://www.semanticscholar.org/paper/005cf4e51408179ec4be8576ecb43acd2c6a56bc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. Nir Lipsman
2. E. Nestler
3. Peter W. Kalivas
4. Andres M. Lozano
5. Alvaro Pascual-Leone
6. Steven C. Cramer
7. Leonardo G. Cohen
8. Helen S. Mayberg

Citations in the corpus

• The role of the posterior cingulate cortex in cognition and disease. (2014, background): “Similarly, responders to deep brain stimulation showed increased glucose metabolism and regional cerebral blood flow in the PCC, accompanying a more complex pattern of alterations in the sub-genual cingulate target region (Mayberg et al., 2005; Lozano et al., 2008).”
• Harnessing neuroplasticity for clinical applications (2011, positive): “…targeting the subcallosal cortex (Brodmann area 25) and its adjacent white matter tracts have shown promise in treating depression, suggesting that disruption of the pathological limbic-cortical circuit may ameliorate treatment-resistant depression (Mayberg et al., 2005; Lozano et al., 2008).”
• Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, positive): “Effects of deep brain stimulation (DBS) on brain metabolic activity a) In treatment-resistant depression, DBS applied to the nucleus accumbens and nearby regions produces significant clinical improvement as well as changes in metabolic activity across an array of neural substrates (as measured by fl”
• Probing and regulating dysfunctional circuits using deep brain stimulation. (2013, positive): “Third, in some cases, neutralizing, disrupting, or, on the other hand, driving activity at these sites can reestablish the functional integrity and ultimately the effective output of the involved circuits leading to a clinical benefit (Lozano et al., 2008).”
• Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “Of note, the subgenual ACC [Broadman Area (BA) 25] is the target of successful attempts to restore normal mood in highly treatment resistant depressed patients (Lozano et al., 2008).”
• Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior (2012, background): “Finally, it should be noted that administration of an inflammatory stimulus (typhoid vaccination) has been associated with activation of the subgenual ACC, the target of deep brain stimulation strategies in patients with treatment-resistant depression (Lozano et al, 2008).”
• A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease (2010, background): “Advances in neurosurgical techniques and the introduction of deep brain stimulation have made possible the modulation of the activity of several brain circuits, including pain circuits,(23) motor circuits in patients with Parkinson disease,(24,25) essential tremor,(26) dystonia,(27) and Huntington d”