Gold nanocages covered by smart polymers for controlled release with near-infrared light
By Mustafa S. Yavuz, Yiyun Cheng, Jingyi Chen, C. Cobley, Qiang Zhang, Matthew Rycenga, Jingwei Xie, Chulhong Kim, A. Schwartz, Lihong V. Wang and 1 more. Nature Materials, 2009
1,160 citations recorded by the source corpus.
Photosensitive caged compounds have enhanced our ability to address the complexity of biological systems by generating effectors with remarkable spatial/temporal resolutions1-3. The caging effect is typically removed by photolysis with ultraviolet light to liberate the bioactive species. Although this technique has been successfully applied to many biological problems, it suffers from a number of intrinsic drawbacks. For example, it requires dedicated efforts to design and synthesize a precursor compound to the effector. The ultraviolet light may cause damage to biological samples and is only suitable for in vitro studies because of its quick attenuation in tissue4. Here we address these issues by developing a platform based on the photothermal effect of gold nanocages. Gold nanocages represent a class of nanostructures with hollow interiors and porous walls5. They can have strong absorption (for the photothermal effect) in the near-infrared (NIR) while maintaining a compact size. When the surface of a gold nanocage is covered with a smart polymer, the pre-loaded effector can be released in a controllable fashion using a NIR laser. This system works well with various effectors without involving sophiscated syntheses, and is well-suited for in vivo studies due to the high transparency of soft tissue in NIR6.
Subfields: Biomedical Engineering, Electronic, Optical and Magnetic Materials, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/003128d60c2e7a01adeb5c775527853d1a102e44
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In Biomedical Engineering
In Electronic, Optical and Magnetic Materials
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Citations in the corpus
- pH-sensitive nano-systems for drug delivery in cancer therapy. (2014, background): “Stimulus-responsive nanomaterials are termed as ‘smart’, ‘intelligent’, or ‘environmentally sensitive’, and have greater potential than traditional delivery systems (Gao et al., 2013; Kikuchi and Okano, 2002; Yavuz et al., 2009).”
- Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy (2016, positive): “Owing to the excellent NIR optical performance, nanomaterials such as metallic nanostructures, metal-based semiconductor nanoparticles and carbon nanomaterials have been explored and employed as PTT agents or drug release systems in in vivo cancer therapy 6–15 .”
- Aggregation behaviour of gold nanoparticles in saline aqueous media (2014, neutral): “2010), drug delivery (Yavuz et al. 2009; Rastogi et al. 2012), diagnostic (Larguinho and Baptista 2012) and imaging (Sousa et al.”