Role of oxidative stress and DNA damage in human carcinogenesis.

By Thomas B. Kryston, Anastassiya B Georgiev, P. Pissis, A. Georgakilas. Mutation research, 2011

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Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution (2024, background): “Its optical transparency during embryonic and larval stages allows for non-invasive and real-time visualization of the dynamics of gene expression within a living organism [99].”
Drug-Induced Oxidative Stress and Toxicity (2012, background): “It is estimated that there is a steady-state level of approximately one 8-oxoGua lesion per 106 normal nucleosides [12].”
Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury (2011, background): “α particles, high charge and high energy (HZE) particles), the yield of locally multiply damaged (LMDS) sites in DNA is greatly increased [4; 41; 42].”
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1. (2012, background): “For example, oxidative stress can cause or amplify genotoxic stress and stimulate inflammatory responses (Kryston et al. 2011).”