Fast DNA sequencing via transverse electronic transport.

By J. Lagerqvist, Michael Zwolak, M. Di Ventra. Nano letters (Print), 2006

372 citations recorded by the source corpus.

A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, that is, orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the perspective of the genetic makeup of each individual.

Subfields: Biomedical Engineering, Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/0029676953c48975a799ab2a33b4fa5b1112f674

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. Michael Zwolak
2. M. Di Ventra
3. Cees Dekker
4. P. Hänggi
5. Fabio Marchesoni

In Electrical and Electronic Engineering

1. Michael Zwolak
2. M. Di Ventra
3. Andy Thomas
4. Mohammed Affan Zidan
5. Khaled Nabil Salama
6. Yuriy V. Pershin
7. Fabio Marchesoni
8. P. Hänggi

Citations in the corpus

• Transport phenomena in nanofluidics (2008, neutral): “Lagerqvist et al., 2006".”
• Solid-state nanopores. (2007, background): “Theoretical calculations indicate that sequence information can be extracted from a tunnelling current through the DNA bases as measured between two transverse nanoelectrodes located right at the nanopor”
• Colloquium: Physical approaches to DNA sequencing and detection (2007, methodology): “To get an idea about the potential speeds achievable with this method, we estimated that a single run through the 3 billion bases on a single-strand of human DNA would take a raw time of about 7 hours, without parallelization (Lagerqvist et al., 2006).”