The role of the chondrocyte in osteoarthritis.

By M. Goldring. Arthritis & Rheumatism, 2000

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The role of cytokines in cartilage matrix degeneration in osteoarthritis. (2004, background): “growth and differentiation factors on chondrocytes to increase synthetic activity.(47,75,81,108,143) In addition, several cytokines can be classified as modulatory based on their capacity to modulate the activities of the other cytokines (Table 1).”
Primary culture and phenotyping of murine chondrocytes (2008, background): “Chondrocyte cultures remain one of the most powerful tools for investigating intracellular and molecular events associated with chondrocyte differentiation and activatio”
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors (2001, background): “and OA, connective tissue destruction is mediated primarily by chondrocytes, by synovial fibroblasts and on occasion, by osteoclasts [7,10–12].”